High-flow nasal cannula (HFNC) was introduced through the last decade in adult, pediatric, and perinatal care as an alternative to other noninvasive ventilatory interfaces. Its goal is to optimize spontaneous breathing through the reduction of dead space and the creation of positive distending airway pressure. In studies on adult subjects, including clinical trials, there was a clear increase in oxygen delivery achieved by increasing HFNC flow. This was explained by the limitation of oxygen dilution by ambient air and the action of the nasopharynx and oropharynx as an anatomic reservoir that increases the volume of inhaled oxygen for subsequent inhalation. HFNC use in adults with respiratory failure is now considered safe and effective.3,4 Being easy to use and well-tolerated, it can also be used in pediatric emergency departments and during patient transport.5
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