ethyl para methoxycinnamate EPMC ethyl p-methoxycinnamate EPMS

harga tertera adalah harga per gram Ethyl p-methoxycinnamate CAS Registry No.: 24393-56-4 Formal Name: 3-(4-methoxyphenyl)-2E-propenoic acid, ethyl ester Synonyms: EPMC, Ethyl 4-methoxycinnamate, Ethyl para-methoxycinnamate, MF: C12H14O3 FW: 206.2 Purity: ≥98% UV/Vis.: λmax: 277, 310 nm Supplied as: A crystalline solid Storage: -20°C Stability: ≥4 years Information represents the product specifications. Laboratory Procedures Ethyl p-methoxycinnamate (EPMC) is supplied as a crystalline solid. A stock solution may be made by dissolving the EPMC in the solvent of choice, which should be purged with an inert gas. EPMC is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF). The solubility of EPMC in ethanol is approximately 10 mg/ml and approximately 30 mg/ml in DMSO and DMF. Description EPMC is a natural product found in K. galanga and C. zedoaria extracts with anti-inflammatory, antiangiogenic, antifungal, larvicidal, and analgesic activities.1-4 It inhibits COX-1 and COX-2 in vitro (IC50s = 1.12 and 0.83 μM, respectively) and reduces IL-1 and TNF-α production in vivo. 3,4 EPMC inhibits granuloma tissue formation and acts as an analgesic, delaying tail flick time, in a dose-dependent manner in rats.4 It inhibits blood vessel growth in rat aortic explants (IC50 = 91.9 μg/ml). EPMC ( lt;10 μg/ml) also reduces growth of T. rubrum, A. niger, S. cerevisiae, and E. floccosum and is larvicidal (LC50 = 53.64 ppm) against Ae. aegypti. 1,2